Minor role of Cl- secretion in non-cystic fibrosis and cystic fibrosis human nasal epithelium.

@article{RueckesNilges1999MinorRO,
  title={Minor role of Cl- secretion in non-cystic fibrosis and cystic fibrosis human nasal epithelium.},
  author={Claudia Rueckes-Nilges and Ursula Weber and Hermann Lindemann and Gerd M{\"u}nker and Wolfgang Clauss and Wolf Michael Weber},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={1999},
  volume={9 1},
  pages={1-10}
}
Na+ and Cl- currents were studied in primary cultures of human nasal epithelium derived from non-cystic fibrosis (non-CF) and cystic fibrosis (CF) patients. We found that Na+ absorption dominates transepithelial transport and the Na+ current contains an amiloride-sensitive and amiloride-insensitive component. In non-CF tissue both components contribute about equally to the entire short-circuit current (ISC), whereas in CF tissues the major part of the current is amiloride-sensitive. Na+ removal… CONTINUE READING

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