Minor modifications to the phosphate groups and the C3' acyl chain length of lipid A in two Bordetella pertussis strains, BP338 and 18-323, independently affect Toll-like receptor 4 protein activation.

@article{Shah2013MinorMT,
  title={Minor modifications to the phosphate groups and the C3' acyl chain length of lipid A in two Bordetella pertussis strains, BP338 and 18-323, independently affect Toll-like receptor 4 protein activation.},
  author={Nita R. Shah and Sami Albitar-Nehme and Emma J. Kim and Nico Marr and Alexey Novikov and Martine Caroff and R. Castillo Fernandez},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 17},
  pages={11751-60}
}
Lipopolysaccharides (LPS) of Bordetella pertussis are important modulators of the immune system. Interaction of the lipid A region of LPS with the Toll-like receptor 4 (TLR4) complex causes dimerization of TLR4 and activation of downstream nuclear factor κB (NFκB), which can lead to inflammation. We have previously shown that two strains of B. pertussis, BP338 (a Tohama I-derivative) and 18-323, display two differences in lipid A structure. 1) BP338 can modify the 1- and 4'-phosphates by the… CONTINUE READING
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