Minor histocompatibility antigens as targets for T-cell therapy after bone marrow transplantation.

@article{Warren1998MinorHA,
  title={Minor histocompatibility antigens as targets for T-cell therapy after bone marrow transplantation.},
  author={Edus H Warren and Marc A. Gavin and Philip D. Greenberg and Stanley R Riddell},
  journal={Current opinion in hematology},
  year={1998},
  volume={5 6},
  pages={429-33}
}
In allogeneic bone marrow transplantation, differences between donor and recipient at minor histocompatibility loci, which encode allelic proteins containing variant peptide sequences, may result in adverse immune reactions such as graft-versus-host disease (GVHD), or graft rejection, but also a beneficial graft versus leukemia (GVL) response. Some minor H antigens are restricted in their expression to hematopoietic cells, including leukemic progenitors, suggesting it may be possible to… CONTINUE READING

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