Minor histocompatibility antigens: targets for tumour therapy and transplant tolerance.

@article{Spierings2008MinorHA,
  title={Minor histocompatibility antigens: targets for tumour therapy and transplant tolerance.},
  author={Eric Spierings},
  journal={International journal of immunogenetics},
  year={2008},
  volume={35 4-5},
  pages={363-6}
}
Minor histocompatibility (H) antigens are allogeneic targets of T-cell mediated immune reactivity following allogeneic haematopoietic stem cell transplantation. Depending on the tissue expression profile of the minor H antigens this immune reactivity clinically results in graft-vs-host disease or in graft-vs-leukaemia effects. Targeting haematopoietic-specific minor H antigens by adoptive immunotherapy will evoke leukaemia-specific allo-immune responses, thereby enhancing graft-vs-leukaemia… CONTINUE READING

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