Minor histocompatibility antigens: past, present, and future.

  title={Minor histocompatibility antigens: past, present, and future.},
  author={Eric Spierings},
  journal={Tissue antigens},
  volume={84 4},
Minor histocompatibility (H) antigens are key molecules driving allo-immune responses in both graft-versus-host-disease (GvHD) and in graft-versus-leukemia (GvL) reactivity in human leukocyte antigen (HLA)-matched hematopoietic stem-cell transplantation (HSCT). Dissection of the dual function of minor H antigens became evident through their different modes of tissue and cell expression, i.e. hematopoietic system-restricted or broad. Broadly expressed minor H antigens can cause both GvHD and GvL… CONTINUE READING


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