Minor Antigen Disparities Impede Induction of Long Lasting Chimerism and Tolerance through Bone Marrow Transplantation with Costimulation Blockade

@inproceedings{Bigenzahn2016MinorAD,
  title={Minor Antigen Disparities Impede Induction of Long Lasting Chimerism and Tolerance through Bone Marrow Transplantation with Costimulation Blockade},
  author={Sinda Bigenzahn and Ines Pree and Christoph Klaus and Nina Pilat and Benedikt Mahr and Elisabeth Schwaiger and Patrick Nierlich and Friedrich Wrba and Thomas Wekerle},
  booktitle={Journal of immunology research},
  year={2016}
}
Mixed chimerism and tolerance can be successfully induced in rodents through allogeneic bone marrow transplantation (BMT) with costimulation blockade (CB), but varying success rates have been reported with distinct models and protocols. We therefore investigated the impact of minor antigen disparities on the induction of mixed chimerism and tolerance. C57BL/6 (H2b) mice received nonmyeloablative total body irradiation (3 Gy), costimulation blockade (anti-CD40L mAb and CTLA4Ig), and 2 × 107 bone… CONTINUE READING