Minocycline treatment for HIV-associated cognitive impairment: results from a randomized trial.

@article{Sacktor2011MinocyclineTF,
  title={Minocycline treatment for HIV-associated cognitive impairment: results from a randomized trial.},
  author={Ned Sacktor and Sachiko Miyahara and Lian Deng and Scott Evans and Giovanni Schifitto and B A Cohen and Robert Paul and Kevin VV. Robertson and Bernadette Jarocki and Kimberly K. Scarsi and Robert W. Coombs and M. Christine Zink and Avindra Nath and Erica E. Smith and Ronald J Ellis and Elyse Singer and James Weihe and Sharon McCarthy and Lara Hosey and David B. Clifford},
  journal={Neurology},
  year={2011},
  volume={77 12},
  pages={1135-42}
}
OBJECTIVE We conducted a study of minocycline to assess its safety, tolerability, and efficacy for the treatment of HIV-associated cognitive impairment. METHODS HIV-1-infected individuals with progressive neurocognitive decline were enrolled in a double-blind, placebo-controlled study of minocycline. Participants were randomized to receive minocycline 100 mg or matching placebo orally every 12 hours. The primary efficacy measure was change in a neuropsychological test composite z score (NPZ-8… CONTINUE READING
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