Minocycline to improve neurologic outcome in stroke (MINOS): a dose-finding study.

  title={Minocycline to improve neurologic outcome in stroke (MINOS): a dose-finding study.},
  author={Susan C Fagan and Jennifer L Waller and Fenwick T. Nichols and D. A. Edwards and Luther Creed Pettigrew and Wayne M. Clark and Christiana E Hall and Jeffrey A. Switzer and Adviye Ergul and David C. Hess},
  volume={41 10},
BACKGROUND AND PURPOSE Minocycline is a promising anti-inflammatory and protease inhibitor that is effective in multiple preclinical stroke models. We conducted an early phase trial of intravenous minocycline in acute ischemic stroke. METHODS Following an open-label, dose-escalation design, minocycline was administered intravenously within 6 hours of stroke symptom onset in preset dose tiers of 3, 4.5, 6, or 10 mg/kg daily over 72 hours. Minocycline concentrations for pharmacokinetic analysis… CONTINUE READING
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: assessment of interaction potential

  • Y Murata, A Rosell, RH Scannevin, KJ Rhodes, X Wang, EH Lo
  • 2009

Extension of the thrombolytic window with minocycline in experimental

  • SC Fagan, DJ Edwards, +4 authors DC Hess
  • 2008

MC inhibits poly (ADP ribose) polymerase I at nanomolar concentrations

  • CC Alano, TN Kauppinen, AV Vall, RA. Swanson
  • Proc Natl Acad Sci U S A 2006 June 12 [Epub ahead…
  • 2006
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