Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction.

@article{Mejia2001MinocyclineRT,
  title={Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction.},
  author={R O Sanchez Mejia and Victor O. Ona and Maria Li and Robert Max Friedlander},
  journal={Neurosurgery},
  year={2001},
  volume={48 6},
  pages={1393-9; discussion 1399-401}
}
OBJECTIVE Caspase-1 plays an important functional role mediating neuronal cell death and dysfunction after experimental traumatic brain injury (TBI) in mice. Minocycline, a derivative of the antibiotic tetracycline, inhibits caspase-1 expression. This study investigates whether minocycline can ameliorate TBI-mediated injury in mice. METHODS Brains from mice subjected to traumatic brain injury underwent immunohistochemical analyses for caspase-1, caspase-3, and a neuronal specific marker (NeuN… CONTINUE READING

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