Minocycline protects the blood-brain barrier and reduces edema following intracerebral hemorrhage in the rat.

@article{Wasserman2007MinocyclinePT,
  title={Minocycline protects the blood-brain barrier and reduces edema following intracerebral hemorrhage in the rat.},
  author={Jason K. Wasserman and Lyanne C Schlichter},
  journal={Experimental neurology},
  year={2007},
  volume={207 2},
  pages={227-37}
}
Intracerebral hemorrhage (ICH) results from rupture of a blood vessel in the brain. After ICH, the blood-brain barrier (BBB) surrounding the hematoma is disrupted, leading to cerebral edema. In both animals and humans, edema coincides with inflammation, which is characterized by production of pro-inflammatory cytokines, activation of resident brain microglia and migration of peripheral immune cells into the brain. Accordingly, inflammation is an attractive target for reducing edema following… CONTINUE READING

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