Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model.

Abstract

BACKGROUND Fragile X syndrome (FXS) is the most common single gene inherited form of mental retardation, with behaviours at the extreme of the autistic spectrum. Subjects with FXS and fragile X mental retardation gene knock out (Fmr1 KO) mice, an animal model for FXS, have been shown to exhibit defects in dendritic spine maturation that may underlie… (More)
DOI: 10.1136/jmg.2008.061796

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@article{Bilousova2009MinocyclinePD, title={Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model.}, author={Tina Bilousova and Lorraine E Dansie and Melanie A. Ngo and Jamie Aye and Jonathan R. Charles and Doug Ethell and Iryna Ethell}, journal={Journal of medical genetics}, year={2009}, volume={46 2}, pages={94-102} }