Minocycline prevents dynorphin-induced neurotoxicity during neuropathic pain in rats

@article{Rojewska2014MinocyclinePD,
  title={Minocycline prevents dynorphin-induced neurotoxicity during neuropathic pain in rats},
  author={Ewelina Rojewska and Wioletta Makuch and Barbara Przewlocka and Joanna Mika},
  journal={Neuropharmacology},
  year={2014},
  volume={86},
  pages={301-310}
}
Despite many advances, our understanding of the involvement of prodynorphin systems in the development of neuropathic pain is not fully understood. Recent studies suggest an important role of neuro-glial interactions in the dynorphin effects associated with neuropathic pain conditions. Our studies show that minocycline reduced prodynorphin mRNA levels that were previously elevated in the spinal and/or dorsal root ganglia (DRG) following sciatic nerve injury. The repeated intrathecal… CONTINUE READING
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