Minocycline modulates antigen-specific CTL activity through inactivation of mononuclear phagocytes in patients with HTLV-I associated neurologic disease

@inproceedings{EnoseAkahata2011MinocyclineMA,
  title={Minocycline modulates antigen-specific CTL activity through inactivation of mononuclear phagocytes in patients with HTLV-I associated neurologic disease},
  author={Yoshimi Enose-Akahata and Eiji Matsuura and Yuetsu Tanaka and Unsong Oh and Steven Jacobson},
  booktitle={Retrovirology},
  year={2011}
}
The activation of mononuclear phagocytes (MPs), including monocytes, macrophages and dendritic cells, contributes to central nervous system inflammation in various neurological diseases. In HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), MPs are reservoirs of HTLV-I, and induce proinflammatory cytokines and excess T cell responses. The virus-infected or activated MPs may play a role in immuneregulation and disease progression in patients with HTLV-I-associated neurological… CONTINUE READING
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