Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury.

@article{Arvin2002MinocyclineMP,
  title={Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury.},
  author={Kara L Arvin and Byung Hee Han and Yansheng Du and Sui-zhen Lin and Steven M Paul and David M Holtzman},
  journal={Annals of neurology},
  year={2002},
  volume={52 1},
  pages={54-61}
}
Hypoxic-ischemic brain injury in the perinatal period is a major cause of morbidity and mortality. Presently, there are no proven effective therapies with which to safeguard the human neonatal brain against this type of injury. Minocycline, a semisynthetic tetracycline, has been shown to be neuroprotective in certain adult ischemic injury/stroke and neurodegenerative disease models. However, minocycline's neuroprotective effects have not been assessed after insults to the neonatal brain. We now… CONTINUE READING