Minocycline inhibits the enhancement of antidromic primary afferent stimulation-evoked vasodilation following intradermal capsaicin injection

@article{Gong2010MinocyclineIT,
  title={Minocycline inhibits the enhancement of antidromic primary afferent stimulation-evoked vasodilation following intradermal capsaicin injection},
  author={Kerui Gong and Yue Yue and Xiaoju Zou and Dingge Li and Qing Lin},
  journal={Neuroscience Letters},
  year={2010},
  volume={482},
  pages={177-181}
}
View on Elsevier
europepmc.org
6 Citations
Background Citations
2
Methods Citations
2

Figures from this paper

6 Citations

Minocycline inhibits neurogenic inflammation by blocking the effects of tumor necrosis factor‐α

It is proposed that minocycline is a potential therapeutic drug that can reduce neuronal excitability and neurogenic inflammation by working on SGCs to inhibit the expression of TNF‐α.

Sumatriptan improves the locomotor activity and neuropathic pain by modulating neuroinflammation in rat model of spinal cord injury

Sumatriptan improves functional recovery from SCI through its anti-inflammatory effects and reducing pro-inflammatory and pain mediators.

Spinal Glial Adaptations Occur in a Minimally Invasive Mouse Model of Endometriosis: Potential Implications for Lesion Etiology and Persistent Pelvic Pain

This is the first study to describe adaptations in nonneuronal, immune-like cells of the central nervous system attributed to the presence of endometriosis-like lesions, and spinal levels showing the greatest alterations in GFAP immunoreactivity appeared to correlate with the spatial location of lesions within the abdominopelvic cavity.

Minocycline as a promising therapeutic strategy for chronic pain.

Effect of preemptive local injection of ropivocaine with dexmedetomidine on mirror pain in rats and its mechanism.

Intrathecal injection of fluorocitric acid inhibits the activation of glial cells causing reduced mirror pain in rats

Fluorocitrate can inhibit the activation of glial cells in spinal cord and DRG, and reduce MIP.

References

SHOWING 1-10 OF 52 REFERENCES

Dorsal root reflexes and cutaneous neurogenic inflammation after intradermal injection of capsaicin in rats.

It is concluded that peripheral cutaneous inflammation induced by intradermal injection of capsaicin involves central nervous mechanisms and DRRs play a major role in the development of neurogenic Cutaneous inflammation, although a direct action of CAP on peripheral nerve terminals or the generation of axon reflexes also may contribute to changes in the skin near the injection site.

Sensitization of primary afferent nociceptors induced by intradermal capsaicin involves the peripheral release of calcitonin gene-related Peptide driven by dorsal root reflexes.

Minocycline attenuates mechanical allodynia and central sensitization following peripheral second-degree burn injury.

The effects of sympathetic outflow on upregulation of vanilloid receptors TRPV1 in primary afferent neurons evoked by intradermal capsaicin

Minocycline reduces the injury-induced expression of prodynorphin and pronociceptin in the dorsal root ganglion in a rat model of neuropathic pain

Cellular Mechanisms of Neurogenic Inflammation

The challenge remains to ascertain the critical transduction pathways that regulate transmitter release from sensory neurons since this phenomenon triggers neurogenic inflammation, and the cellular mechanisms involved in alterations in neuronal excitability during injury and the Cellular pathways that maintain the inflammatory response over time need to be determined.

Intrathecal minocycline attenuates peripheral inflammation‐induced hyperalgesia by inhibiting p38 MAPK in spinal microglia

Findings show that minocycline given IT produces a potent and consistent antinociception in models of tissue injury and inflammation‐evoked pain, and they provide strong support for the idea that this effect is mediated by direct inhibition of spinal microglia and subsequent activation of p38 in these cells.

Calcitonin gene-related peptide produces skeletal muscle vasodilation following antidromic stimulation of unmyelinated afferents in the dorsal root in rats

Dorsal root potentials and dorsal root reflexes: a double-edged sword

Evidence is reviewed that links DRRs to a substantial part of the swelling of the knee joint in acute experimental arthritis and to the flare reaction in the skin following intradermal injection of capsaicin.

Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors

The hypothesis that the Vi/Vc transition zone is involved in deep orofacial injury is supported and glial inhibition and interruption of the cytokine cascade after inflammation may provide pain relief.
...