Minocycline inhibits neurogenic inflammation by blocking the effects of tumor necrosis factor‐α

  title={Minocycline inhibits neurogenic inflammation by blocking the effects of tumor necrosis factor‐$\alpha$},
  author={Kerui Gong and Xiaoju Zou and Perry N. Fuchs and Qing Lin},
  journal={Clinical and Experimental Pharmacology and Physiology},
  • Kerui GongX. Zou Qing Lin
  • Published 1 September 2015
  • Biology, Chemistry
  • Clinical and Experimental Pharmacology and Physiology
It has been well established that neurogenic inflammation is one of the major pathological processes underlying inflammatory pain, but there are few effective anti‐inflammatory drugs to alleviate such pain. The present study shows that minocycline, a widely used glial activation inhibitor, is effective in reducing neurogenic inflammation. Patch‐clamp recordings showed that small sized dorsal root ganglion (DRG) neurons were dramatically excited following intradermal capsaicin injection in the… 

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