Minocycline inhibits neurogenic inflammation by blocking the effects of tumor necrosis factor‐α
@article{Gong2015MinocyclineIN, title={Minocycline inhibits neurogenic inflammation by blocking the effects of tumor necrosis factor‐$\alpha$}, author={Kerui Gong and Xiaoju Zou and Perry N. Fuchs and Qing Lin}, journal={Clinical and Experimental Pharmacology and Physiology}, year={2015}, volume={42} }
It has been well established that neurogenic inflammation is one of the major pathological processes underlying inflammatory pain, but there are few effective anti‐inflammatory drugs to alleviate such pain. The present study shows that minocycline, a widely used glial activation inhibitor, is effective in reducing neurogenic inflammation. Patch‐clamp recordings showed that small sized dorsal root ganglion (DRG) neurons were dramatically excited following intradermal capsaicin injection in the…
16 Citations
Minocycline Inhibits the Enhanced Antidromic Stimulation-induced Sensitization of C-Fibers Following Intradermal Capsaicin Injection
- BiologyThe Open Pain Journal
- 2019
It is shown that minocycline pretreatment significantly blocked the priming effect of capsaicin on C-fiber sensitization induced by antidromic ES, indicating the involvement of SGCs in DRG neuronal sensitization.
The role of chemical transmitters in neuron-glia interaction and pain in sensory ganglion
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Minocycline as a promising therapeutic strategy for chronic pain.
- Medicine, BiologyPharmacological research
- 2018
Prolonged ketamine exposure induces enhanced excitatory GABAergic synaptic activity in the anterior cingulate cortex of neonatal rats
- BiologyNeuroscience Letters
- 2021
Abnormal levels of histone methylation in the retinas of diabetic rats are reversed by minocycline treatment
- BiologyScientific reports
- 2017
Assessment of the alterations of retinal histone post-translational modifications in diabetic rats using a liquid chromatography - tandem mass spectrometry approach indicates that alteration of some histone methylation levels is associated with the development of diabetic retinopathy in rodents, and the beneficial effect of minocycline on the retinas of diabetic rodents is partially through its ability to normalize the altered histonemethylation levels.
Non-neuronal crosstalk promotes an inflammatory response in nodose ganglia cultures after exposure to byproducts from gram positive, high-fat-diet-associated gut bacteria
- BiologyPhysiology & Behavior
- 2020
Minocycline augmentation in older adults with persistent depression: an open label proof of concept study
- Psychology, MedicineInternational Psychogeriatrics
- 2020
ABSTRACT Less than 40% of depressed older adults treated with an antidepressant achieve remission. Incomplete response to treatment is common. Current augmentation strategies have limited efficacy,…
The clinical efficacy of minocycline mouth rinse on recurrent aphthous stomatitis—A randomized controlled trial
- MedicineIndian journal of dental research : official publication of Indian Society for Dental Research
- 2022
The 0.5% minocycline mouth rinse prescribed along with vitamin supplement and topical anesthetic gel and vitamin supplement prescribed alone for the treatment of RAS had shown more reduction in the pain symptoms when compared to topical anesthesia gel and vitamins prescribed alone.
Persistent adaptation by chronic alcohol is facilitated by neuroimmune activation linked to stress and CRF.
- Biology, PsychologyAlcohol
- 2016
Patch Clamp Recordings on Intact Dorsal Root Ganglia from Adult Rats.
- BiologyJournal of visualized experiments : JoVE
- 2016
A method to prepare intact DRGs and conduct patch clamp recordings on individual primary sensory neurons ex vivo, which avoids axonal injury from manipulation and enzyme digestion such as when dissociating DRGs.
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