Minocycline inhibits neurogenic inflammation by blocking the effects of tumor necrosis factor‐α

@article{Gong2015MinocyclineIN,
  title={Minocycline inhibits neurogenic inflammation by blocking the effects of tumor necrosis factor‐$\alpha$},
  author={Kerui Gong and Xiaoju Zou and Perry N. Fuchs and Qing Lin},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={2015},
  volume={42}
}
  • Kerui GongX. Zou Qing Lin
  • Published 1 September 2015
  • Biology, Chemistry
  • Clinical and Experimental Pharmacology and Physiology
It has been well established that neurogenic inflammation is one of the major pathological processes underlying inflammatory pain, but there are few effective anti‐inflammatory drugs to alleviate such pain. The present study shows that minocycline, a widely used glial activation inhibitor, is effective in reducing neurogenic inflammation. Patch‐clamp recordings showed that small sized dorsal root ganglion (DRG) neurons were dramatically excited following intradermal capsaicin injection in the… 
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16 Citations

Minocycline Attenuates Microglia/Macrophage Phagocytic Activity and Inhibits SAH-Induced Neuronal Cell Death and Inflammation

A significantly reduced phagocytic activity of microglia/macrophages accompanied by a lowered spatial interaction with neurons and reduced neuronal apoptosis achieved by minocycline administration after SAH is observed.

Tumor necrosis factor‐α mediated pain hypersensitivity through Ret receptor in resiniferatoxin neuropathy

Minocycline Inhibits the Enhanced Antidromic Stimulation-induced Sensitization of C-Fibers Following Intradermal Capsaicin Injection

It is shown that minocycline pretreatment significantly blocked the priming effect of capsaicin on C-fiber sensitization induced by antidromic ES, indicating the involvement of SGCs in DRG neuronal sensitization.

Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy

Metformin could be considered as an alternative therapeutic agent for SCI, as it potentially attenuates neuroinflammation, sensory and locomotor complications of cord injury.

The role of chemical transmitters in neuron-glia interaction and pain in sensory ganglion

Minocycline as a promising therapeutic strategy for chronic pain.

Prolonged ketamine exposure induces enhanced excitatory GABAergic synaptic activity in the anterior cingulate cortex of neonatal rats

Abnormal levels of histone methylation in the retinas of diabetic rats are reversed by minocycline treatment

Assessment of the alterations of retinal histone post-translational modifications in diabetic rats using a liquid chromatography - tandem mass spectrometry approach indicates that alteration of some histone methylation levels is associated with the development of diabetic retinopathy in rodents, and the beneficial effect of minocycline on the retinas of diabetic rodents is partially through its ability to normalize the altered histonemethylation levels.

Non-neuronal crosstalk promotes an inflammatory response in nodose ganglia cultures after exposure to byproducts from gram positive, high-fat-diet-associated gut bacteria

The clinical efficacy of minocycline mouth rinse on recurrent aphthous stomatitis—A randomized controlled trial

The 0.5% minocycline mouth rinse prescribed along with vitamin supplement and topical anesthetic gel and vitamin supplement prescribed alone for the treatment of RAS had shown more reduction in the pain symptoms when compared to topical anesthesia gel and vitamins prescribed alone.

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