Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum

@article{He2001MinocyclineIM,
  title={Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum},
  author={Yun Yang He and Stanley Appel and Weidong Le},
  journal={Brain Research},
  year={2001},
  volume={909},
  pages={187-193}
}
To determine the role of immune/inflammatory factors in dopaminergic cell degeneration in parkinsonian substantia nigra, we assayed tyrosine hydroxylase (TH)-positive immunoreactive neuronal numbers with stereologic techniques and CD11b-positive immunoreactive microglial profiles following 6-hydroxydopamine (6-OHDA) injection into ipsilateral striatum of mice. We further investigated the effect of minocycline on the inhibition of microglial activation and subsequent protection of nigral cells… CONTINUE READING
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