Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

  title={Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease},
  author={M. Chen and V. Ona and M. Li and R. Ferrante and K. Fink and S. Zhu and J. Bian and L. Guo and L. Farrell and Steve M. Hersch and Wendy R. Hobbs and Jean-Paul G. Vonsattel and J. Cha and R. Friedlander},
  journal={Nature Medicine},
  • M. Chen, V. Ona, +11 authors R. Friedlander
  • Published 2000
  • Medicine
  • Nature Medicine
  • Huntington disease is an autosomal dominant neurodegenerative disease with no effective treatment. Minocycline is a tetracycline derivative with proven safety. After ischemia, minocycline inhibits caspase-1 and inducible nitric oxide synthetase upregulation, and reduces infarction. As caspase-1 and nitric oxide seem to play a role in Huntington disease, we evaluated the therapeutic efficacy of minocycline in the R6/2 mouse model of Huntington disease. We report that minocycline delays disease… CONTINUE READING
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    Paper Mentions

    The goals of this trial are to determine if coenzyme Q10 is effective in slowing the worsening symptoms of Huntington's disease and to learn about the safety and acceptability of… Expand
    ConditionsHuntington's Disease
    InterventionDrug, Other
    The purpose of this study is to determine whether the addition of minocycline or placebo to treatment as usual (TAU): 1. prevents the accumulation of negative symptoms and… Expand
    ConditionsFirst Episode Psychosis
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