Minocycline inhibits West Nile virus replication and apoptosis in human neuronal cells.

@article{Michaelis2007MinocyclineIW,
  title={Minocycline inhibits West Nile virus replication and apoptosis in human neuronal cells.},
  author={Martin Michaelis and Malte Christian Kleinschmidt and Hans Wilhelm Doerr and Jindrich Cinatl},
  journal={The Journal of antimicrobial chemotherapy},
  year={2007},
  volume={60 5},
  pages={981-6}
}
OBJECTIVES West Nile virus (WNV) infection causes severe meningitis and encephalitis in a subset of patients. WNV-induced apoptosis has been suggested to contribute to WNV pathogenesis. Tetracyclines exert antiviral effects against HIV and inhibit apoptosis in different models of neuronal disease. Here, the effects of the tetracyclines minocycline, demeclocycline and chlortetracycline were observed on WNV replication and WNV-induced apoptosis in different human CNS-derived cell types (primary… CONTINUE READING