Minocycline in phenotypic models of Huntington's disease.

  title={Minocycline in phenotypic models of Huntington's disease.},
  author={Kadiombo Bantubungi and Carine Jacquard and Anita Greco and Annita Pintor and Abdelwahed Chtarto and Khalid Tai and M Galas and Liliane Tenenbaum and Nicole D{\'e}glon and Patrizia Popoli and Luisa Minghetti and Emmanuel Brouillet and Jacques Brotchi and Marc Levivier and Serge N Schiffmann and David M. Blum},
  journal={Neurobiology of disease},
  volume={18 1},
Minocycline has been shown to be neuroprotective in various models of neurodegenerative diseases. However, its potential in Huntington's disease (HD) models characterized by calpain-dependent degeneration and inflammation has not been investigated. Here, we have tested minocycline in phenotypic models of HD using 3-nitropropionic acid (3NP) intoxication and quinolinic acid (QA) injections. In the 3NP rat model, where the development of striatal lesions involves calpain, we found that… CONTINUE READING