Minocycline in active rheumatoid arthritis. A double-blind, placebo-controlled trial.

@article{Kloppenburg1994MinocyclineIA,
  title={Minocycline in active rheumatoid arthritis. A double-blind, placebo-controlled trial.},
  author={Margreet Kloppenburg and Ferdinand C. Breedveld and J P Terwiel and C Mall{\'e}e and Ben A. C. Dijkmans},
  journal={Arthritis and rheumatism},
  year={1994},
  volume={37 5},
  pages={629-36}
}
OBJECTIVE To determine the efficacy of minocycline in the treatment of rheumatoid arthritis (RA). METHODS Minocycline (maximal oral daily dose 200 mg) or placebo was administered in a 26-week, randomized, double-blind study to 80 patients with active RA, who were treated or had previously been treated with at least one disease-modifying antirheumatic drug. RESULTS There were 15 premature discontinuations: 6 (5 taking minocycline) because of adverse effects, 8 (all taking placebo) because of… CONTINUE READING