Minocycline decreases in vitro microglial motility, beta1-integrin, and Kv1.3 channel expression.

@article{NutileMcMenemy2007MinocyclineDI,
  title={Minocycline decreases in vitro microglial motility, beta1-integrin, and Kv1.3 channel expression.},
  author={Nancy Nutile-McMenemy and Ary{\'e} Elfenbein and Joyce A Deleo},
  journal={Journal of neurochemistry},
  year={2007},
  volume={103 5},
  pages={2035-46}
}
Minocycline is a semisynthetic, tetracycline derivative that exerts anti-inflammatory and neuroprotective effects unrelated to its anti-microbial action. We have previously shown that minocycline prevented peripheral nerve injury-induced mechanical allodynia. Minocycline's mechanisms of action as a neuroprotective and anti-allodynic agent are unknown. In response to injury, microglia become activated, proliferate, and migrate. Resting microglia express voltage-dependent inward K(+) currents and… CONTINUE READING