Minocycline chelates Ca2+, binds to membranes, and depolarizes mitochondria by formation of Ca2+-dependent ion channels.

@article{Antonenko2010MinocyclineCC,
  title={Minocycline chelates Ca2+, binds to membranes, and depolarizes mitochondria by formation of Ca2+-dependent ion channels.},
  author={Yuri N Antonenko and Tatyana I Rokitskaya and Arthur J. L. Cooper and Boris F. Krasnikov},
  journal={Journal of bioenergetics and biomembranes},
  year={2010},
  volume={42 2},
  pages={151-63}
}
Minocycline (an anti-inflammatory drug approved by the FDA) has been reported to be effective in mouse models of amyotrophic lateral sclerosis and Huntington disease. It has been suggested that the beneficial effects of minocycline are related to its ability to influence mitochondrial functioning. We tested the hypothesis that minocycline directly inhibits the Ca(2+)-induced permeability transition in rat liver mitochondria. Our data show that minocycline does not directly inhibit the… CONTINUE READING