Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion.

@article{Cho2006MinocyclineAW,
  title={Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion.},
  author={Kyung-Ok Cho and Hyen Oh La and Young-jin Cho and Ki-Wug Sung and Seong Yun Kim},
  journal={Journal of neuroscience research},
  year={2006},
  volume={83 2},
  pages={285-91}
}
White matter lesions are thought to result from chronic cerebral ischemia and constitute a core pathology of subcortical vascular dementia. This rarefaction has been known to be associated with microglial activation. We investigated whether minocycline, a microglial inhibitor, attenuates the white matter damage induced by chronic cerebral hypoperfusion that is used as a model of vascular dementia. Male Wistar rats were subjected to bilateral, permanent occlusion of the common carotid arteries… CONTINUE READING

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