Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation.

@article{Ledeboer2005MinocyclineAM,
  title={Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation.},
  author={Annemarie Ledeboer and Evan M. Sloane and Erin D. Milligan and Matthew G Frank and John H Mahony and Steven F. Maier and Linda R. Watkins},
  journal={Pain},
  year={2005},
  volume={115 1-2},
  pages={71-83}
}
Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating enhanced pain states by releasing proinflammatory cytokines and other substances thought to facilitate pain transmission. In the present study, we report that intrathecal administration of minocycline, a selective inhibitor of microglial cell activation, inhibits low threshold mechanical allodynia, as measured by the von Frey test, in two models of pain facilitation. In a rat model of neuropathic… CONTINUE READING
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