Minocycline as a neuroprotective agent.

  title={Minocycline as a neuroprotective agent.},
  author={David P. Stirling and Kaveh M Koochesfahani and John D. Steeves and Wolfram Tetzlaff},
  journal={The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  volume={11 4},
Several studies have shown that minocycline, a semisynthetic, second-generation tetracycline derivative, is neuroprotective in animal models of central nervous system trauma and several neurodegenerative diseases. Common to all these reports are the beneficial effects of minocycline in reducing neural inflammation and preventing cell death. Here, the authors review the proposed mechanisms of action of minocycline and suggest that minocycline may inhibit several aspects of the inflammatory… CONTINUE READING
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