Minocycline ameliorates hypoxia-induced blood-brain barrier damage by inhibition of HIF-1α through SIRT-3/PHD-2 degradation pathway.

@article{Yang2015MinocyclineAH,
  title={Minocycline ameliorates hypoxia-induced blood-brain barrier damage by inhibition of HIF-1α through SIRT-3/PHD-2 degradation pathway.},
  author={Fan Yang and Li Zhou and Dong Wang and Zhengguo Wang and Qing-yuan Huang},
  journal={Neuroscience},
  year={2015},
  volume={304},
  pages={250-9}
}
BACKGROUND Minocycline, a second-generation tetracycline alleviates neuro-inflammation and protects the blood-brain barrier (BBB) in ischemia stroke. However, the effect of minocycline in hypoxia-induced BBB damage is unclear. Here, we have investigated the effect of minocycline under hypoxia and explored its possible underlying mechanisms. METHODS The effect of minocycline was examined in vitro in Human Brain Microvascular Endothelial Cells (HBMECs) using Trans Epithelial Electric Resistance… CONTINUE READING
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