Minocycline: stain devil?

@article{Good2003MinocyclineSD,
  title={Minocycline: stain devil?},
  author={Michael L. Good and David Hussey},
  journal={British Journal of Dermatology},
  year={2003},
  volume={149}
}
Summary  Minocycline is the treatment of choice for acne vulgaris, the most common form of inflammatory acne, despite the increase in awareness of rare but significant side‐effects. This paper discusses the undesirable side‐effect of minocycline staining in permanent teeth. 
Still leaving stains on teeth-the legacy of minocycline?
TLDR
A case of staining to only the crowns of unerupted third molars in a girl prescribed minocycline at age 16 for papulopustular acne is reported, highlighting current deficiencies in the disclosure information for minocyCline.
Drug Induced Tooth Discolouration
TLDR
Drugs that have the potential to induce tooth discoloration (intrinsic and extrinsic), Pathophysiology Mechanism and Treatment.
Modifying Minocycline's Structure to Reduce Risks of Teeth Staining
TLDR
This study investigated the particular interaction between minocycline and the protein active site, which helped predict more efficacious designs of this drug.
Minocycline and its extended-release formulation for the treatment of moderate-to-severe acne vulgaris
TLDR
The main advantage of this new extended-release formulation is the lower incidence of vestibular side effects; however, presently, there are no trials comparing the efficacy of this formulation to other formulations of minocycline in the treatment of acne.
Black bone disease of the foot: a case study of minocycline-induced bone pigmentation
TLDR
A case of a patient with a prior history of long-term minocycline use who was identified to have black bone disease of the first metatarsal during bunion correction surgery is provided.
A Review of Systemic Minocycline Side Effects and Topical Minocycline as a Safer Alternative for Treating Acne and Rosacea
TLDR
Adverse effects and drug–drug interactions observed with oral administration of minocycline are reviewed and this with topical minocyCline formulations recently approved or under development for effectively treating dermatological disorders with fewer adverse effects and less drug interaction are compared.
Drug‐induced dental disorders
TLDR
Teeth may be discoloured, for example by tetracyclines, and they may be physically damaged by erosion or by formulations containing sucrose.
Minocycline-Induced Bone Discoloration: A Case Report.
TLDR
The incidence of minocycline-induced discoloration of bone is unknown since it is more commonly found as an incidental finding during routine surgical procedures, however, staining of adult dentition has been reported to occur in 3% to 6% of patients on long-term minocyCline.
Doxycycline-induced staining of permanent adult dentition.
TLDR
The observations indicate that the incidence of staining of the permanent dentition, as a complication of doxycycline, may be much higher than the literature indicates, especially if treatment is administered during summer months.
Acne vulgaris: a review of antibiotic therapy
  • A. Tan, H. Tan
  • Medicine
    Expert opinion on pharmacotherapy
  • 2005
TLDR
It is essential that clinicians prescribing antibiotics for the treatment of acne adopt strategies to minimise further development of bacterial resistance, including addressing compliance issues, using combination therapies, avoiding prolonged antibiotic treatment, and avoiding concomitant topical and oral antibiotics with che-mically dissimilar antibiotics.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 20 REFERENCES
Minocycline-induced discoloration of the permanent teeth.
TLDR
A patient in whom a blue-gray pigmentation of the teeth developed after the administration of minocycline therapy for acne is reported to be a case report of this unusual adverse reaction.
The management of rosacea
  • A. Sober
  • Medicine
    Dermatology nursing
  • 1992
TLDR
The condition differs clinically from acne vulgaris and the old name of acne rosacea is misleading, although its cause remains unknown, it can now be treated with remarkable success.
Erythema dyschromicum perstans and lichen planus: are they related?
TLDR
A 53-year-old woman initially had lichen planus primarily on her extremities and lesions consistent with erythema dyschromicum perstans were observed, which cleared with griseofulvin therapy but returned after discontinuation of the drug.
Minocycline-associated tooth discoloration in young adults.
TLDR
After observing a patient with adult-onset tooth discoloration coincident with minocycline administration, a cohort of patients with severe cystic acne during therapeutic trials with isotretinoin was surveyed and minocyCline must be considered as an uncommon cause of tooth staining in adults.
[Side effects of minocycline in the treatment of acne vulgaris].
TLDR
The clinical efficacy of minocycline in the treatment of acne vulgaris is better than that of tetracycline and equal to that of doxycycline and the serious adverse events consist of hyperpigmentation of various tissues, autoimmune disorders and serious hypersensitivity reactions.
Minocycline-induced intraoral pharmacogenic pigmentation: case reports and review of the literature.
TLDR
If minocycline use becomes widespread as a treatment for rheumatoid arthritis, it is likely that more practitioners will be asked to diagnose this sometimes striking, though apparently benign, condition.
Anxiety, depression, and nature of acne vulgaris in adolescents
TLDR
This data indicates that acne has been related to psychiatric morbidity for many years and improved treatment may have modified its prevalence and severity.
Efficacy of minocycline compared with tetracycline in treatment of acne vulgaris
TLDR
Although the differences between treatment groups were not statistically significant at any evaluation, more patients treated with minocycline reached and maintained a noninflammatory acne status in less time than did patientstreated with tetracycline.
Lymecycline and Minocycline in Inflammatory Acne
TLDR
In this trial, minocycline 100/50 mg was superior for the treatment of inflammatory acne when compared to lymecycline 300 mg and minocyCline 50 mg.
Acne therapy: clinical pearls.
TLDR
Several classes of medications successfully treat acne, but one must consider the potential side effects of each treatment and make sure that the benefits outweigh the risks of the treatment and the side effects can be safely treated.
...
1
2
...