Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson's disease.

@article{Dixit2013MinocyclineLA,
  title={Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson's disease.},
  author={Anubhuti Dixit and Garima Srivastava and Divya Ratan Verma and Manisha Mishra and Pradhyumna Kumar Singh and Om Prakash and Mahendra Pratap Singh},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1832 8},
  pages={1227-40}
}
Mitochondrial dysfunction is the foremost perpetrator of the nigrostriatal dopaminergic neurodegeneration leading to Parkinson's disease (PD). However, the roles played by majority of the mitochondrial proteins in PD pathogenesis have not yet been deciphered. The present study investigated the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and combined maneb and paraquat on the mitochondrial proteome of the nigrostriatal tissues in the presence or absence of minocycline… CONTINUE READING

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