Minireview. The nephrotoxicity of cisplatin.

  title={Minireview. The nephrotoxicity of cisplatin.},
  author={Robin S. Goldstein and Gilbert H. Mayor},
  journal={Life sciences},
  volume={32 7},
Cisplatin is a cancer chemotherapeutic agent whose clinical use is complicated by its dose related kidney toxicity. Since the histopathological profile of cisplatin nephrotoxicity appears similar to that of other heavy metals, it has been commonly presumed that cisplatin nephrotoxicity is related to the platinum moiety. However, the delayed time course and development of cisplatin nephrotoxicity is not characteristic of heavy metal nephropathy. Furthermore, cisplatin nephrotoxicity is… CONTINUE READING

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