Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging.

@article{Bartke2005MinireviewRO,
  title={Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging.},
  author={Andrzej Bartke},
  journal={Endocrinology},
  year={2005},
  volume={146 9},
  pages={
          3718-23
        }
}
The important role of IGF and insulin-related signaling pathways in the control of longevity of worms and insects is very well documented. In the mouse, several spontaneous or experimentally induced mutations that interfere with GH biosynthesis, GH actions, or sensitivity to IGF-I lead to extended longevity. Increases in the average life span in these mutants range from approximately 20-70% depending on the nature of the endocrine defect, gender, diet, and/or genetic background. Extended… CONTINUE READING
Highly Cited
This paper has 146 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
Showing 1-10 of 104 citations

146 Citations

01020'08'11'14'17
Citations per Year
Semantic Scholar estimates that this publication has 146 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 80 references