Minireview: human obesity-lessons from monogenic disorders.

  title={Minireview: human obesity-lessons from monogenic disorders.},
  author={Stephen O'Rahilly and I Sadaf Farooqi and Giles S. H. Yeo and Benjamin G Challis},
  volume={144 9},
Genetic influences on the determination of human fat mass are profound and powerful, a statement that does not conflict with the obvious influence of environmental factors that drive recent changes in the prevalence of obesity. The assertion of the importance of genetic factors has, until recently, largely been based on twin and adoption studies. However, in the last 6 yr, a number of human genes have been identified in which major missense or nonsense mutations are sufficient in themselves to… CONTINUE READING

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