Minireview: does in-vitro testing of oximes help predict their in-vivo action after paraoxon exposure?

@article{Lorke2009MinireviewDI,
  title={Minireview: does in-vitro testing of oximes help predict their in-vivo action after paraoxon exposure?},
  author={Dietrich E Lorke and Georg A Petroianu},
  journal={Journal of applied toxicology : JAT},
  year={2009},
  volume={29 6},
  pages={459-69}
}
K-oximes have recently been developed in the search for efficacious broad-band reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OPC). Before clinical use, their toxicity and efficacy need to be assessed, and there is clear demand for simple in vitro tests that can predict in vivo performance. This article summarizes our in vitro data obtained for conventional and experimental oximes in human and rat blood exposed to the OPC paraoxon and correlates them with… CONTINUE READING
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