Minireview: Secondary β-Cell Failure in Type 2 Diabetes-A Convergence of Glucotoxicity and Lipotoxicity.

@article{Poitout2002MinireviewS,
  title={Minireview: Secondary β-Cell Failure in Type 2 Diabetes-A Convergence of Glucotoxicity and Lipotoxicity.},
  author={Vincent Poitout and R. Paul Robertson},
  journal={Endocrinology},
  year={2002},
  volume={143 2},
  pages={339-342}
}
Chronic hyperglycemia and hyperlipidemia can exert deleterious effects on -cell function, respectively referred to as glucotoxicity and lipotoxicity. Over time, both contribute to the progressive deterioration of glucose homeostasis characteristic of type 2 diabetes. The mechanisms of glucotoxicity involve several transcription factors and are, at least in part, mediated by generation of chronic oxidative stress. Lipotoxicity is probably mediated by accumulation of a cytosolic signal derived… CONTINUE READING
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