Minireview: Pref-1: role in adipogenesis and mesenchymal cell fate.

@article{Sul2009MinireviewPR,
  title={Minireview: Pref-1: role in adipogenesis and mesenchymal cell fate.},
  author={Hei Sook Sul},
  journal={Molecular endocrinology},
  year={2009},
  volume={23 11},
  pages={
          1717-25
        }
}
Preadipocyte factor-1 [Pref-1; also called Dlk1 (Delta-like protein 1)] is made as an epidermal growth factor-repeat containing transmembrane protein that produces a biologically active soluble form by TNF-alpha-converting enzyme (TACE)-mediated cleavage. Soluble Pref-1 activates the MAPK kinase/ERK pathway. In adipose tissue, Pref-1 is specifically expressed in preadipocytes but not in adipocytes and thus is used as a preadipocyte marker. Inhibition of adipogenesis by Pref-1 has been well… CONTINUE READING

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