Mining tissue specificity, gene connectivity and disease association to reveal a set of genes that modify the action of disease causing genes

@article{Reverter2008MiningTS,
  title={Mining tissue specificity, gene connectivity and disease association to reveal a set of genes that modify the action of disease causing genes},
  author={Antonio Reverter and Aaron Ingham and Brian P. Dalrymple},
  journal={BioData Mining},
  year={2008},
  volume={1},
  pages={8 - 8}
}
The tissue specificity of gene expression has been linked to a number of significant outcomes including level of expression, and differential rates of polymorphism, evolution and disease association. Recent studies have also shown the importance of exploring differential gene connectivity and sequence conservation in the identification of disease-associated genes. However, no study relates gene interactions with tissue specificity and disease association. We adopted an a priori approach making… CONTINUE READING
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Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes

  • L Franke, H van Bakel, L Fokkens, ED de Jong, M Egmont-Petersen, C Wijmenga
  • Am J Hum Genet
  • 2006
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