Mining the metabiome: identifying novel natural products from microbial communities.

  title={Mining the metabiome: identifying novel natural products from microbial communities.},
  author={Aleksandr Milshteyn and Jessica S Schneider and Sean F. Brady},
  journal={Chemistry & biology},
  volume={21 9},
Microbial-derived natural products provide the foundation for most of the chemotherapeutic arsenal available to contemporary medicine. In the face of a dwindling pipeline of new lead structures identified by traditional culturing techniques and an increasing need for new therapeutics, surveys of microbial biosynthetic diversity across environmental metabiomes have revealed enormous reservoirs of as yet untapped natural products chemistry. In this review, we touch on the historical context of… CONTINUE READING
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