Mining the archival formalin-fixed paraffin-embedded tissue proteome: opportunities and challenges.

@article{Nirmalan2008MiningTA,
  title={Mining the archival formalin-fixed paraffin-embedded tissue proteome: opportunities and challenges.},
  author={Niroshini J. Nirmalan and Patricia A Harnden and Peter John Selby and Rosamonde E. Banks},
  journal={Molecular bioSystems},
  year={2008},
  volume={4 7},
  pages={712-20}
}
The significant potential of tissue-based proteomic biomarker studies can be restricted by difficulties in accessing samples in optimal fresh-frozen form. While archival formalin-fixed tissue collections with attached clinical and outcome data represent a valuable alternate resource, the use of formalin as a fixative which induces protein cross-linking, has generally been assumed to render them unsuitable for proteomic studies. However, this view has been challenged recently with the… CONTINUE READING

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