Mining the acute respiratory distress syndrome proteome: identification of the insulin-like growth factor (IGF)/IGF-binding protein-3 pathway in acute lung injury.

@article{Schnapp2006MiningTA,
  title={Mining the acute respiratory distress syndrome proteome: identification of the insulin-like growth factor (IGF)/IGF-binding protein-3 pathway in acute lung injury.},
  author={Lynn M. Schnapp and Samuel M Donohoe and Jinzhi Chen and Donald A Sunde and Patricia M Kelly and John T. Ruzinski and Thomas J Martin and David R. Goodlett},
  journal={The American journal of pathology},
  year={2006},
  volume={169 1},
  pages={86-95}
}
To obtain a more complete protein profile of the airspace milieu in acute respiratory distress syndrome (ARDS) and to identify new mediators, we analyzed bronchoalveolar lavage fluid (BALF) by shotgun proteomics. Using BALF from three patients, we identified a total of 870 different proteins, a nearly 10-fold increase from previous reports. Among the proteins identified were known markers of lung injury, such as surfactant, proteases, and serum proteins. We also identified several biologically… CONTINUE READING

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