Mining the B cell repertoire for broadly neutralizing monoclonal antibodies to HIV-1.

Abstract

Monoclonal antibodies that effectively neutralize HIV-1 have been widely sought, yet few have been isolated. Now, technological advances in sera evaluation, B cell stimulation, microneutralization, and antibody cloning have allowed Burton and colleagues to identify two broadly neutralizing monoclonal antibodies, PG9 and PG16, which provide insights for HIV… (More)
DOI: 10.1016/j.chom.2009.09.008

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