Mining protein complexes based on connected affinity clique extension

  title={Mining protein complexes based on connected affinity clique extension},
  author={Peng Li and Xiaohua Hu and Tingting He and Junmin Zhao and Ming Zhang and Xianjun Shen},
  journal={2013 IEEE International Conference on Bioinformatics and Biomedicine},
A novel algorithm based on Connected Affinity Clique Extension (CACE) for mining overlapping functional modules in protein interaction network is proposed in this paper. In this approach, the value of protein connected affinity is interpreted as the reliability and possibility of interaction which is inferred from protein complexes. The protein interaction network is constructed as a weighted graph, and the weigh is dependent on the connected affinity coefficient. The experimental results of… CONTINUE READING
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