Mining of public sequencing databases supports a non-dietary origin for putative foreign miRNAs: underestimated effects of contamination in NGS.

@article{Tosar2014MiningOP,
  title={Mining of public sequencing databases supports a non-dietary origin for putative foreign miRNAs: underestimated effects of contamination in NGS.},
  author={Juan Pablo Tosar and Carlos Rovira and Hugo Naya and Alfonso M. Cayota},
  journal={RNA},
  year={2014},
  volume={20 6},
  pages={754-7}
}
The report that exogenous plant miRNAs are able to cross the mammalian gastrointestinal tract and exert gene-regulation mechanism in mammalian tissues has yielded a lot of controversy, both in the public press and the scientific literature. Despite the initial enthusiasm, reproducibility of these results was recently questioned by several authors. To analyze the causes of this unease, we searched for diet-derived miRNAs in deep-sequencing libraries performed by ourselves and others. We found… CONTINUE READING
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