Mining of a streptothricin gene cluster from Streptomyces sp. TP-A0356 genome via heterologous expression

@article{Li2013MiningOA,
  title={Mining of a streptothricin gene cluster from Streptomyces sp. TP-A0356 genome via heterologous expression},
  author={Jine Li and Zhengyan Guo and Wei Huang and Xiangxi Meng and Guomin Ai and Gongli Tang and Yihua Chen},
  journal={Science China Life Sciences},
  year={2013},
  volume={56},
  pages={619-627}
}
Streptothricins (STs) are used commercially to treat bacterial and fungal diseases in agriculture. Mining of the sequenced microbial genomes uncovered two cryptic ST clusters from Streptomyces sp. C and Streptomyces sp. TP-A0356. The ST cluster from S. sp. TP-A0356 was verified by successful heterologous expression in Streptomyces coelicolor M145. Two new… CONTINUE READING

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