Mining disease susceptibility genes through SNP analyses and expression profiling using MALDI-TOF mass spectrometry.

@article{Tang2004MiningDS,
  title={Mining disease susceptibility genes through SNP analyses and expression profiling using MALDI-TOF mass spectrometry.},
  author={Kai Tang and Paul A Oeth and Stefan Kammerer and Mikhail F. Denissenko and Jonas Ekblom and Christian Jurinke and Dirk van den Boom and Andreas Braun and Charles R. Cantor},
  journal={Journal of proteome research},
  year={2004},
  volume={3 2},
  pages={218-27}
}
To find genes that underlie disease susceptibilities, genome-wide single nucleotide polymorphisms (SNPs) have been analyzed using high-throughput matrix assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS). As a proof-of-concept for this approach, gene regions have been identified that were previously associated by others with certain diseases or traits. On the same technology platform, accurate and absolute transcriptional profiling can be performed and… CONTINUE READING

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