Mining Quasi-Bicliques from HIV-1-Human Protein Interaction Network: A Multiobjective Biclustering Approach

  title={Mining Quasi-Bicliques from HIV-1-Human Protein Interaction Network: A Multiobjective Biclustering Approach},
  author={Ujjwal Maulik and Anirban Mukhopadhyay and Malay Bhattacharyya and Lars Kaderali and Benedikt Brors and Sanghamitra Bandyopadhyay and Roland Eils},
  journal={IEEE/ACM Transactions on Computational Biology and Bioinformatics},
In this work, we model the problem of mining quasi-bicliques from weighted viral-host protein-protein interaction network as a biclustering problem for identifying strong interaction modules. In this regard, a multiobjective genetic algorithm-based biclustering technique is proposed that simultaneously optimizes three objective functions to obtain dense biclusters having high mean interaction strengths. The performance of the proposed technique has been compared with that of other existing… CONTINUE READING
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