Minimum requirements for efficient transduction of dividing and nondividing cells by feline immunodeficiency virus vectors.

@article{Johnston1999MinimumRF,
  title={Minimum requirements for efficient transduction of dividing and nondividing cells by feline immunodeficiency virus vectors.},
  author={Julie C. Johnston and Mehdi Gasmi and Leland E. Lim and John H. Elder and Jiing Kuan Yee and Douglas J Jolly and Kevin P Campbell and Beverly L. Davidson and Sybille L Sauter},
  journal={Journal of virology},
  year={1999},
  volume={73 6},
  pages={4991-5000}
}
The development of gene delivery vectors based on feline immunodeficiency virus (FIV) is an attractive alternative to vectors based on primate sources for the delivery of genes into humans. To investigate the requirements for efficient transduction of dividing and nondividing cells by vector particles based on FIV, a series of packaging and vector constructs was generated for which viral gene expression was minimized and from which unnecessary cis-acting sequences were deleted. Pseudotyped… CONTINUE READING

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