Minimum infectious dose of hepatitis B virus in chimpanzees and difference in the dynamics of viremia between genotype A and genotype C.

@article{Komiya2008MinimumID,
  title={Minimum infectious dose of hepatitis B virus in chimpanzees and difference in the dynamics of viremia between genotype A and genotype C.},
  author={Yutaka Komiya and Keiko Katayama and Hisao Yugi and Masaaki Mizui and Harumichi Matsukura and Tetsushi Tomoguri and Yuzo Miyakawa and Ayako Tabuchi and Junko Tanaka and H. Yoshizawa},
  journal={Transfusion},
  year={2008},
  volume={48 2},
  pages={286-94}
}
BACKGROUND In planning optimal hepatitis B virus (HBV) blood screening strategies, the minimum infectious dose and early dynamics of HBV need to be determined for defining the window period for HBV DNA as well as for hepatitis B surface antigen (HBsAg). STUDY DESIGN AND METHODS Pairs of chimpanzees were inoculated with preacute-phase inocula containing HBV of genotype A or genotype C to determine the minimum infectious dose, and two pairs of chimps infected with the lowest infectious dose of… CONTINUE READING

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