Minimotif Miner: A Computational Tool to Investigate Protein Function, Disease, and Genetic Diversity

@article{Schiller2007MinimotifMA,
  title={Minimotif Miner: A Computational Tool to Investigate Protein Function, Disease, and Genetic Diversity},
  author={Martin R. Schiller},
  journal={Current Protocols in Protein Science},
  year={2007},
  volume={48}
}
  • M. Schiller
  • Published 1 May 2007
  • Biology, Computer Science
  • Current Protocols in Protein Science
The Minimotif Miner Web site contains information on several hundred short functional motifs in a single database, and allows the user to search protein queries for the presence of these motifs. Scoring based on evolutionary conservation, protein surface prediction, and motif frequency can be used in conjunction with other motif programs and the known biology of the query to reduce false‐positive predictions and select short motifs for experimental pursuit. 

Minimotif Miner 3.0: database expansion and significantly improved reduction of false-positive predictions from consensus sequences

TLDR
The third release of the MnM database is reported, which has now grown 60-fold to approximately 300 000 minimotifs, and a new set of false-positive filters and linear regression scoring that vastly enhance minimotIF prediction accuracy on a test data set are summarized.

Minimotif miner 2nd release: a database and web system for motif search

TLDR
This work revised MnM by expanding the database more than 10-fold to approximately 5000 motifs and standardized the motif function definitions, and the web-application user interface has been redeveloped with new features including improved navigation, screencast-driven help, support for alias names and expanded SNP analysis.

C terminus of the P2X7 receptor: treasure hunting

TLDR
The role of the P2X7R C terminus in regards to receptor function is discussed, the specific domains and motifs found therein are described and compared with others proteins to discover predicted domains or sites of PTM are compared.

The EFF-1A Cytoplasmic Domain Influences Hypodermal Cell Fusions in C. elegans But Is Not Dependent on 14-3-3 Proteins

TLDR
Deletion of the EFF-1A endodomain noticeably affects the timing of hypodermal cell fusions in vivo, and the two 14-3-3 proteins in C. elegans, PAR-5 and FTT-2, may regulate either localization or fusion-inducing activity of EFF-0, highlighting the necessity of tight fusogen regulation for proper development.

A Unified Bug Testing Software for Biological and Other Systems

TLDR
This paper reports one such bug testing software that is created for the MnM web system for motif search and feels that the architecture it has employed is generic and can be applied to other software systems as well.

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