Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung.

@article{Duch2011MinimizingOA,
  title={Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung.},
  author={Matthew C. Duch and G. R. Scott Budinger and Yu Teng Liang and Saul Soberanes and Daniela Urich and Sergio E. Chiarella and Laura A. Campochiaro and {\'A}ngel Gonz{\'a}lez and Navdeep S Chandel and Mark C. Hersam and G{\"o}khan M Mutlu},
  journal={Nano letters},
  year={2011},
  volume={11 12},
  pages={5201-7}
}
To facilitate the proposed use of graphene and its derivative graphene oxide (GO) in widespread applications, we explored strategies that improve the biocompatibility of graphene nanomaterials in the lung. In particular, solutions of aggregated graphene, Pluronic dispersed graphene, and GO were administered directly into the lungs of mice. The introduction of GO resulted in severe and persistent lung injury. Furthermore, in cells GO increased the rate of mitochondrial respiration and the… CONTINUE READING
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