Minimizing inhibition of PCR-STR typing using digital agarose droplet microfluidics.

  title={Minimizing inhibition of PCR-STR typing using digital agarose droplet microfluidics.},
  author={Tao Geng and Richard A Mathies},
  journal={Forensic science international. Genetics},
The presence of PCR inhibitors in forensic and other biological samples reduces the amplification efficiency, sometimes resulting in complete PCR failure. Here we demonstrate a high-performance digital agarose droplet microfluidics technique for single-cell and single-molecule forensic short tandem repeat (STR) typing of samples contaminated with high concentrations of PCR inhibitors. In our multifaceted strategy, the mitigation of inhibitory effects is achieved by the efficient removal of… CONTINUE READING
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